Tadjudin, Noer Saelan and Tanra, Andi Jayalangkara and Islam, Andi Asadul and As’ad, Suryani and Massi, Muh. Nasrum and Patellongi, Ilhamjaya and Prihantono, Prihantono (2018) Association of Apolipoprotein E Polymorphism with Cognitive Functions in Elderly. Indian Journal of Public Health Research & Development, 9 (12).
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Abstract
Objective: This study aims to examine the association between apolipoprotein E polymorphism (APOE)
and cognitive functions test using Montreal Cognitive Assesment- Indonesian version 2012 (MoCA-Ina) in
elderly.
Method: A cross-sectional study of 112 elderly participants from two nursing homes in Jakarta. APOE gene
polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism
(PCR-RFLP).
Results: There are four genotypes: E2/E2 10(8.9%), E3/E3 38(33.9%), E3/E4 46(41.1%) and E4/E4
18(16.1%). The percentage of E2 allele 20(8.9%), E3 122(54.5%), E4 82(36.6%). The cognitive function
test, MoCA-Ina ≥ 26: 34(40%) participants with genotype E2/E2 3(8.8%), E3/E3 7(20.6%), E3/E4
16(47.1%) and E4/E4 8(23.5%). MoCA-Ina < 26: 51(60%) 51 participants with genotype E2/E2 7(13.7%),
E3/E3 14(27.5%), E3/E4 22(43.1%) and E4/E4 8(15.7%). A significant relationship between APOE
gene polymorphism with MoCA-Ina-abstraction: E3/E4 vs. E3/E3 p 0.019, E4/E4 vs. E3/E3 p = 0.028, a
significant relationship between APOE gene polymorphism with MoCA-Ina-language: E3/E4 vs. E2/E2 p
= 0.03, E4/E4 vs. E2/E2 p 0.029, and a significant relationship between APOE gene polymorphism with
naming: E3/E4 vs. E2/E2 p = 0.048.
Conclusion: High percentage of APOE allele E4 may be one of the causes of high cognitive function decline.
APOE gene polymorphisms associated with the decreased cognitive function; abstraction, language, and
naming. Allele E4 may be a potential factor for cognitive function decline.
| Item Type: | Article |
|---|---|
| Subjects: | Artikel Penelitian > Fakultas Kedokteran |
| Divisions: | Fakultas Kedokteran > Kedokteran |
| Depositing User: | Erik Wijaya |
| Date Deposited: | 24 Jun 2022 02:52 |
| Last Modified: | 24 Jun 2022 02:52 |
| URI: | https://repotest.untar.ac.id/id/eprint/36497 |
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