Culturing Neurons on MEMS Fabricated P(VDF-TrFE) Films for Implantable Artificial Cochlea*

Tanujaya, Harto Culturing Neurons on MEMS Fabricated P(VDF-TrFE) Films for Implantable Artificial Cochlea*. Culturing Neurons on MEMS Fabricated P(VDF-TrFE) Films for Implantable Artificial Cochlea*.

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Abstract

In this paper, we report an in vitro study on the biocompatibility of poly(vinylidene
fluoride-trifluoroethylene) (P(VDF-TrFE)) films for the implantable artificial
cochlea. The implantable artificial cochlea comprises a piezoelectric membrane
made of P(VDF-TrFE), platinum (Pt) thin film electrodes, and a silicon substrate
which are designed to stimulate neurons in a cochlea and fabricated by
microelectromechanical systems (MEMS) and thin film technologies. The
biocompatibility of P(VDF-TrFE) film is evaluated by culturing cerebral cortical
neurons from rats on it. The fibronectin from human plasma and the collagen from
the calf skin are used as the cell adhesion factors. Since neurons extend dendrites
and axons from the somata, it is found that the neurons are successfully cultured on
the surface of P(VDF-TrFE) films modified both by the fibronectin and by the
collagen. Furthermore, it is also found that the neurons are also successfully
cultured over the Pt electrode on the P(VDF-TrFE) of the implantable artificial
cochlea modified by the fibronectin. Consequently, the biocompatibility and the
applicability of the MEMS fabricated P(VDF-TrFE) films and the implantable
artificial cochlea are confirmed.

Item Type:	Article
Subjects:	Penelitian > Fakultas Teknik
Divisions:	Fakultas Teknik > Teknik Mesin
Depositing User:	Puskom untar untar
Date Deposited:	10 Mar 2021 07:22
Last Modified:	10 Mar 2021 07:22
URI:	https://repotest.untar.ac.id/id/eprint/14831

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