Encapsulated Lime Peel Essential Oil (Citrus hystrix) Into Chitosan Nanoparticle: New Entity to Enhanced Effectivity Against Propionilbacterium Acne in Vitro

Wijayadi, Linda Julianti and Rusli, Taty Rusliati Encapsulated Lime Peel Essential Oil (Citrus hystrix) Into Chitosan Nanoparticle: New Entity to Enhanced Effectivity Against Propionilbacterium Acne in Vitro. Encapsulated Lime Peel Essential Oil (Citrus hystrix) Into Chitosan Nanoparticle: New Entity to Enhanced Effectivity Against Propionilbacterium Acne in Vitro.

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Abstract

Acne Vulgaris (AV) is a chronic inflammatory disease that affects 85% of the
population at least once throughout their lives. The pathogenesis of AV including
hypercolonization in pilosebaseous glands by P. acnes. Effective and efficient acne therapeutics
including topical acne medications remain a crucial aspect of acne research. The lime peel essential
oil contains triterpenoid steroid and has antibacterial effect against P. acnes. Chitosan is a natural
material produced by deacetylyation of chitin from crustacean exoskeleton. Being biocompatible,
biodegradable, and affordable, chitosan is widely explored in biomedical field as active agent or
drug carrier. In this study, the lime peel essential oil was encapsulated into chitosan nanoparticle
through ionotropic gelation technique to be formulated into topical acne cream preparation. The
aim of this study was to evaluate and to compare the efficacy of encapsulated and non
encapsulated lime peel essential oil into chitosan nanoparticle in inhibiting P. acnes. The
inhibition zone of P. acnes which known as non-growth area after exposure to lime peel essential
oil encapsulated into chitosan nanoparticle was calculated. The result showed chitosan
nanoparticle formula led to an inhibitory zone of 20,61 mm in diameter, while non-encapsulated
formula only led to 10-20 mm. Result led to conclusion that chitosan nanoparticle encapsulation
formulation led to improved
P. acnes inhibitory activity of lime peel essential oil.

Item Type:	Article
Subjects:	Penelitian > Fakultas Kedokteran
Depositing User:	Puskom untar untar
Date Deposited:	29 Dec 2020 09:05
Last Modified:	29 Dec 2020 09:09
URI:	https://repotest.untar.ac.id/id/eprint/13970

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